外科学講座 【末盛5階】
研究
 
 
 
研究内容
 私たちは主に消化器癌を中心として、癌の発生や進展に関与する遺伝子の同定や消化器炎症性疾患の病態メカニズムを解明することを目指して研究を進めています。
 また、癌そのものの異常を同定することと同時に、癌が発生する母体である正常組織ですでに癌を作りやすい異常が起きていないか、ということに注目しています。
 あるいは歯学部外科である特徴を生かし、歯科口腔領域の疾患と消化器癌や消化器炎症性疾患との関連についても研究を進めつつあります。
3-02
研究実績
2016年
【総説・論文】
Kanda M, Kobayashi D, Tanaka C, Iwata N, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Nomoto S, Murotani K, Fujiwara M, Kodera Y. : Adverse prognostic impact of perioperative allogeneic transfusion on patients with stage II/III gastric cancer. Gastric Cancer, 19(1):255-63, 2016.
Fujii T, Yamada S, Murotani K, Sugimoto H, Hattori M, Kanda M, Takami H, Nakayama G, Nomoto S, Fujiwara M, Nakao A, Kodera Y.: Modified Blumgart Suturing Technique for Remnant Closure After Distal Pancreatectomy: a Propensity Score-Matched Analysis. J Gastrointest Surg, 20(2):374-84, 2016.
Kanda M, Nomoto S, Oya H, Takami H, Shimizu D, Hibino S, Hashimoto R, Kobayashi D, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y. : The Expression of Melanoma-Associated Antigen D2 Both in Surgically Resected and Serum Samples Serves as Clinically Relevant Biomarker of Gastric Cancer Progression. Ann Surg Oncol, 23(Suppl 2):214-21, 2016.
Yamada S, Fujii T, Suzuki K, Inokawa Y, Kanda M, Nakayama G, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Nakao A, Kodera Y.: Preoperative Identification of a Prognostic Factor for Pancreatic Neuroendocrine Tumors Using Multiphase Contrast-Enhanced Computed Tomography. Pancreas., 45(2):198-203, 2016.
Niwa Y, Koike M, Hattori M, Iwata N, Takami H, Hayashi M, Kanda M, Kobayashi D, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Nomoto S, Fujiwara M, Kodera Y. : Short-term outcomes after conventional transthoracic esophagectomy. Nagoya J Med Sci, 78(1):69-78, 2016.
Shimizu D, Kanda M, Sugimoto H, Sueoka S, Takami H, Ezaka K, Tanaka Y, Hashimoto R, Okamura Y, Iwata N, Tanaka C, Yamada S, Fujii T, Nakayama G, Koike M, Nomoto S, Fujiwara M, Kodera Y.: NRAGE promotes the malignant phenotype of hepatocellular carcinoma. Oncol Lett., 11(3):1847-1854, 2016.
Inokawa Y, Sonohara F, Kanda M, Hayashi M, Nishikawa Y, Sugimoto H, Kodera Y, Nomoto S. Correlation Between Poor Prognosis and Lower TPPP Gene Expression in Hepatocellular Carcinoma. Anticancer Res, 36(9):4639-45, 2016.
Inokawa Y, Inaoka K, Sonohara F, Hayashi M, Kanda M, Nomoto S.: Molecular alterations in the carcinogenesis and progression of hepatocellular carcinoma: Tumor factors and background liver factors (Review). Oncology Letters, 12(5): 3662-3668, 2016.
Kanda M, Shimizu D, Fujii T, Tanaka H, Tanaka Y, Ezaka K, Shibata M, Takami H,Hashimoto R, Sueoka S, Iwata N, Kobayashi D, Tanaka C, Yamada S, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y. : Neurotrophin Receptor-Interacting Melanoma Antigen-Encoding Gene Homolog is Associated with Malignant Phenotype of Gastric Cancer. Ann Surg Oncol, 23(Suppl 4):532-539, 2016.
Kanda M, Tanaka C, Kobayashi D, Tanaka H, Shimizu D, Shibata M, Takami H,Hayashi M, Iwata N, Niwa Y, Yamada S, Fujii T, Nakayama G, Fujiwara M, Kodera Y.: Epigenetic suppression of the immunoregulator MZB1 is associated with themalignant phenotype of gastric cancer. Int J Cancer, 139(10):2290-8, 2016.
Kanda M, Shimizu D, Fujii T, Tanaka H, Shibata M, Iwata N, Hayashi M, Kobayashi D, Tanaka C, Yamada S, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y.: Protein arginine methyltransferase 5 is associated with malignant phenotype and peritoneal metastasis in gastric cancer. Int J Oncol, 49(3):1195-202, 2016.
八谷文貴、清水 大、杉田好彦、野本周嗣、冨士谷盛興、千田 彰. 種々の照射条件でHe-Neレーザー照射した各種培養細胞の増殖活性におけるLow Level Lasar Therapy (LLLT)効果. 日本歯科保存学雑誌, 59(6):509-515, 2016.
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【学会発表】
野本周嗣:HCC再発の腫瘍リスク因子および背景肝リスク因子となるIncRNAの同定とその臨床応用. 平成27年度(第41回)冲中記念成人病研究所研究報告会(東京)2016.3.5
清水 大、神田光郎、高見秀樹、林 真路、岩田直樹、小林大介、田中千恵、山田 豪、中山吾郎、杉本博行、小池聖彦、藤原道隆、藤井 努、小寺泰弘:肝細胞癌におけるProtein arginine methyltransferase 5の役割に関する検討.第116回日本外科学会定期学術集会(大阪)2016.4.15
Yoshikuni Inokawa, Kenichi Inaoka, Fuminori Sonohara, Hisaharu Oya, Masamichi Hayashi, Yukiko Niwa, Naoki Iwata, Daisuke Kobayashi, Masahiko Koike, Yasuhiro Kodera, Shuji Nomoto:Correlation between the expression of Sox2, Oct4 and deltaNp63 in clinical samples of resected esophageal cancers. AACR Annual Meeting 2016 (American Association for Cancer Research),(America)2016.4.19
清水 大、丹羽由紀子、二宮 豪、岩田直樹、小林大介、小池聖彦、藤原道隆、小寺泰弘:右胃大網動脈の梗塞が原因と考えられた胃管壊死の一例.第70回食道学会学術集会(東京)2016.7.6
清水 大、神田光郎、小林大介、田中千恵、中山吾郎、杉本博行、小池聖彦、藤原道隆、藤井 努、小寺泰弘:Transcriptome 解析により胃癌肝転移関連分子として検出した GPR155 の発現および機能解析.第 71 回日本消化器外科学会総会(徳島)2016.7.15
清水 大:Transcriptome解析により胃癌肝転移関連分子として検出したGPR155の発現および機能解析.第27回日本消化器癌発生学会総会(鹿児島)2016.9.16
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2015年
【総説・論文】
Hishida M, Inokawa Y, Takano N, Nishikawa Y, Iwata N, Kanda M, Tanaka C, Kobayashi D, Yamada S, Nakayama G, Fujii T, Sugimoto H, Koike M, Fujiwara M, Kodera Y, Nomoto S: Protein tyrosine kinase 7: a hepatocellular carcinoma-related gene detected by triple-combination array. J Surg Res, 195(2):444-53, 2015.
Kanda M, Oya H, Nomoto S, Takami H, Shimizu D, Hashimoto R, Sueoka S, Kobayashi D, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y: Diversity of clinical implication of B-cell translocation gene 1 expression by histopathologic and anatomic subtypes of gastric cancer. Dig Dis Sci, 60(5):1256-64, 2015.
Takano N, Hishida M, Inokawa Y, Hayashi M, Kanda M, Nishikawa Y, Iwata N, Kobayashi D, Tanaka C, Yamada S, Nakayama G, Fujii T, Sugimoto H, Koike M, Fujiwara M, Kodera Y, Nomoto S: CCNJ detected by triple combination array analysis as a tumor-related gene of hepatocellular carcinoma. Int J Oncol, 46(5):1963-70, 2015.
Kanda M, Shimizu D, Nomoto S, Takami H, Hibino S, Oya H, Hashimoto R, Suenaga M, Inokawa Y, Kobayashi D, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y. Prognostic impact of expression and methylation status of DENN/MADD domain-containing protein 2D in gastric cancer. Gastric Cancer, 18(2):288-96, 2015.
Sonohara F, Nomoto S, Inokawa Y, Kanda M, Yamada S, Fujii T, Sugimoto H, Kodera Y: Serosal invasion strongly associated with recurrence after curative hepatic resection of hepatocellular carcinoma: a retrospective study of 214 consecutive cases. Medicine (Baltimore), 94(9):e602, 2015.
Kanda M, Sugimoto H, Nomoto S, Oya H, Hibino S, Shimizu D, Takami H, Hashimoto R, Okamura Y, Yamada S, Fujii T, Nakayama G, Koike M, Fujiwara M, Kodera Y: B-cell translocation gene 1 serves as a novel prognostic indicator of hepatocellular carcinoma. Int J Oncol, 46(2):641-8, 2015.
Sonohara F, Nomoto S, Inokawa Y, Hishida M, Takano N, Kanda M, Nishikawa Y, Fujii T, Koike M, Sugimoto H, Kodera Y. High expression of Janus kinase 2 in background normal liver tissue of resected hepatocellular carcinoma is associated with worse prognosis. Oncol Rep, 33(2):767-73, 2015.
Inaoka K, Inokawa Y, Nomoto S: Genomic-Wide Analysis with Microarrays in Human Oncology. Microarrays. 4:454-473.2015.
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【学会発表】
Sonohara F, Nomoto S, Inokawa Y, Kanda M, Yamada S, Fujii T, Sugimoto H, Koike M, Fujiwara M, Kodera Y: SEROSAL INVASION SHOULD BE CONSIDERED AS ONE OF THE STRONGEST PROGNOSTIC FACTORS AFTER CURATIVE RESECTION OF HEPATOCELLULAR CARCINOMA: A RETROSPECTIVE SEARCH FOR CONSECUTIVE 275 CASES.5th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association (A-PHPBA), (Singapore)2015.3.18
Nomoto S, Sonohara F, Inokawa Y, Kanda M, Sugimoto H, Fujiwara M, Koike M, Fujii T, Kodera Y: RISK FACTORS FOR RECURRENCE FREE SURVIVAL AFTER CURATIVE HEPATECTOMY IN HEPATOCELLULAR CARCINOMA, A PREDICTION OF RECURRENCE’S TERM AND TYPE. 5th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association (A-PHPBA) , (Singapore)2015.3.18
野本周嗣,園原史訓,猪川祥邦,菱田光洋,神田光郎,杉本博行,藤井 努,小池聖彦,藤原道隆,小寺泰弘: 肝細胞癌術後の早期,中期,晩期再発におけるリスクとなる腫瘍因子と背景肝因子の検討. 第115回日本外科学会定期学術集会,(名古屋)2015.4.17
Nomoto S, Sonohara F, Inokawa Y, Kanda M, Fujii T, Sugimoto H, Koike M, Fujiwara M, Kodera Y: Alteration of aldo-keto reductase family 1, member B10(AKR1B10) expression among tumor and background non-tumorous tissue of curatively resected hepatocellular carcinoma is associated with worse prognosis. AACR Annual Meeting 2015 (American Association for Cancer Research),(America)2015.4.21
園原史訓,野本周嗣,猪川祥邦,神田光郎,山田 豪,藤井 努,杉本博行,小池聖彦,藤原道隆,小寺泰弘:肝細胞がんの背景肝におけるインフラマソーム構成分子の遺伝子発現と予後との関連の検討.第73回日本消化器外科学会総会,(浜松)2015.7.15.
野本周嗣,園原史訓,猪川祥邦,菱田光洋,神田光郎,藤井 努,小池聖彦,杉本博行,藤原道隆,小寺泰弘:切除治癒後HCCの腫瘍と背景肝とにおけるAKR1B10遺伝子発現の大小と予後との関係についての検討.第71回日本消化器外科学会総会,(浜松)2015.7.16
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2014年
【総説・論文】
Nomoto S, Hishida M, Inokawa Y, Takano N, Kanda M, Nishikawa Y, Fujii T, Masahiko Koike, Hiroyuki Sugimoto, Yasuhiro Kodera. Expression Analysis of THOP1 in Background Liver, a Prognostic Predictive Factor in Hepatocellular Carcinoma, Extracted by Multiarray Analysis.Ann SurgOncol, 21(suppl 3): 443−450, 2014.
Nomoto S, Hishida M, Inokawa Y, Sugimoto H, Kodera Y.Management of hepatocellular carcinoma should consider both tumor factors and background liver factors.Hepatobiliary SurgNutr, 3(2): 82-5, 2014.
Hayashi M, Nomoto S, Hishida M, Inokawa Y, Kanda M, Okamura Y, Nishikawa Y, Tanaka C, Kobayashi D, Yamada S, Nakayama G, Fujii T, Sugimoto H, Koike M, Fujiwara M, Takeda S, Kodera Y.Identification of the collagen type 1 α 1 gene (COL1A1) as a candidate survival-related factor associated with hepatocellular carcinoma. BMC Cancer, 14:108, 2014.
Shimizu D, Kanda M,Nomoto S, Oya H, Takami H, Hibino S, Suenaga M, Inokawa Y, Hishida M, Takano N, Nishikawa Y, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y. Identification of intragenic methylation in the TUSC1 gene as a novel prognostic marker of hepatocellular carcinoma.Oncol Rep, 31(3):1305-13, 2014.
Yamada S, Fujii T, Shimoyama Y, Kanda M, Nakayama G, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Nakao A, Kodera Y.Clinical implication of morphological subtypes in management of intraductal papillary mucinous neoplasm.Ann SurgOncol, 21(7):2444-52, 2014.
Nakayama G, Tanaka C, Uehara K, Mashita N, Hayashi N, Kobayashi D, Kanda M, Yamada S, Fujii T, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Ando Y, Kodera Y.The impact of dose/time modification in irinotecan- and oxaliplatin-based chemotherapies on outcomes in metastatic colorectal cancer.Cancer ChemotherPharmacol, 73(4):847-55, 2014.
Kanda M, Shimizu D, Nomoto S, Takami H, Hibino S, Oya H, Hashimoto R, Suenaga M, Inokawa Y, Kobayashi D, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y.Prognostic impact of expression and methylation status of DENN/MADD domain-containing protein 2D in gastric cancer.Gastric Cancer,[Epub ahead of print] 2014.
Kanda M, Shimizu D,Nomoto S, Hibino S, Oya H, Takami H, Kobayashi D, Yamada S, Inokawa Y, Tanaka C, Fujii T, Sugimoto H, Koike M, Fujiwara M, Kodera Y. Clinical significance of expression and epigenetic profiling of TUSC1 in gastric cancer.J SurgOncol,110(2):136-44, 2014.
Kanda M, Fujii T, Suenaga M, Takami H, Inokawa Y, Yamada S, Kobayashi D, Tanaka C, Sugimoto H, Nomoto S, Fujiwara M, Kodera Y. Pancreatoduodenectomy with portal vein resection is feasible and potentially beneficial for elderly patients with pancreatic cancer. Pancreas,43(6):951-8, 2014.
Fujii T, Sugimoto H, Yamada S, Kanda M, Suenaga M, Takami H, Hattori M, Inokawa Y, Nomoto S, Fujiwara M, Kodera Y. Modified Blumgart anastomosis for pancreaticojejunostomy: technical improvement in matched historical control study.J GastrointestSurg,18(6):1108-15, 2014.
Yamamura K, Sugimoto H, Kanda M, Yamada S, Nomoto S, Nakayama G, Fujii T, Koike M, Fujiwara M, Kodera Y. Comparison of inflammation-based prognostic scores as predictors of tumor recurrence in patients with hepatocellular carcinoma after curative resection.J Hepatobiliary PancreatSci,21(9):682-8, 2014.
Yamada S, Okumura N, Wei L, Fuchs BC, Fujii T, Sugimoto H, Nomoto S, Takeda S, Tanabe KK, Kodera Y.Epithelial to mesenchymal transition is associated with shorter disease-free survival in hepatocellular carcinoma.Ann SurgOncol, 21(12):3882-90, 2014.
Niwa Y, Yamada S, Koike M, Kanda M, Fujii T, Nakayama G, Sugimoto H, Nomoto S, Fujiwara M, Kodera Y. Epithelial to mesenchymal transition correlates with tumor budding and predicts prognosis in esophageal squamous cell carcinoma.J SurgOncol, 110(6):764-9, 2014.
Mashita N, Yamada S, Nakayama G, Tanaka C, Iwata N, Kanda M, Kobayashi D, Fujii T, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Kodera Y. Epithelial to mesenchymal transition might be induced via CD44 isoform switching in colorectal cancer.J SurgOncol,110(6):745-51, 2014.
Torii K, Yamada S, Nakamura K, Tanaka H, Kajiyama H, Tanahashi K, Iwata N, Kanda M, Kobayashi D, Tanaka C, Fujii T, Nakayama G, Koike M, Sugimoto H, Nomoto S, Natsume A, Fujiwara M, Mizuno M, Hori M, Saya H, Kodera Y. Effectiveness of plasma treatment on gastric cancer cells.Gastric Cancer,[Epub ahead of print] 2014.
Kanda M, Fujii T, Suenaga M, Takami H, Hattori M, Inokawa Y, Yamada S, Nakayama G, Sugimoto H, Koike M, Nomoto S, Kodera Y.Estimated pancreatic parenchymal remnant volume accurately predicts clinically relevant pancreatic fistula after pancreatoduodenectomy. Surgery.156(3):601-10, 2014.
Kanda M, Fujii T, Takami H, Suenaga M, Inokawa Y, Yamada S, Kobayashi D, Tanaka C, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Kodera Y.Novel diagnostics for aggravating pancreatic fistulas at the acute phase after pancreatectomy.World J Gastroenterol, 20(26):8535-44, 2014.
Inokawa Y, Sugimoto H, Kanda M, Yamada S, Fujii T, Nomoto S, Takeda S, Suzuki N, Matsushita T, Kodera Y.Hepatectomy for hepatocellular carcinoma in patients with hemophilia.J Hepatobiliary PancreatSci,21(11):824-8, 2014.
Kanda M, Nomoto S, Oya H, Shimizu D, Takami H, Hibino S, Hashimoto R, Kobayashi D, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y.Dihydropyrimidinase-like 3 facilitates malignant behavior of gastric cancer.J ExpClin Cancer Res, 33(1):66, 2014.
Oya H, Kanda M, Sugimoto H, Shimizu D, Takami H, Hibino S, Hashimoto R, Okamura Y, Yamada S, Fujii T, Nakayama G, Koike M, Nomoto S, Fujiwara M, Kodera Y.Dihydropyrimidinase-like 3 is a putative hepatocellular carcinoma tumor suppressor.J Gastroenterol, [Epub ahead of print] 2014.
Kanda M, Sugimoto H, Nomoto S, Oya H, Shimizu D, Takami H, Hashimoto R, Sonohara F, Okamura Y, Yamada S, Fujii T, Nakayama G, Koike M, Fujiwara M, Kodera Y. Clinical utility of PDSS2 expression to stratify patients at risk for recurrence of hepatocellular carcinoma.Int J Oncol, 45(5):2005-12, 2014.
Kanda M, Nomoto S, Oya H, Hashimoto R, Takami H, Shimizu D, Sonohara F, Kobayashi D, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Murotani K, Fujiwara M, Kodera Y.Decreased expression of prenyl diphosphate synthase subunit 2 correlates with reduced survival of patients with gastric cancer.J ExpClin Cancer Res,33(1):88, 2014.
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愛知学院大学 歯学部〒464-8650 名古屋市千種区楠元町1-100TEL 052-751-2561(代)

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